The Complex Life of mRNA:
From Synthesis to Decay
EMBL Heidelberg, Germany Thursday 18 March - Saturday 20 March 2010
The regulation of gene expression has been studied traditionally at the level of transcription. While a few examples of translational regulation were known, they were considered interesting exceptions to the general rule of regulation at the level of RNA synthesis. However, over the last few years it has become evident that several widespread posttranscriptional, mostly cytoplasmic mechanisms have profound effects on gene expression. All of these mechanisms ultimately contribute to control protein synthesis, either directly, by affecting the rate of translation, or indirectly, by affecting the abundance of mRNA. Some of them exert a qualitative, all-or-none control, for example by complete repression or elimination of certain mRNAs, others determine the intracellular location or the cell-type in which a particular RNA is translated, and still others have a quantitative effect, controlling the amount of protein made from a certain mRNA. The analysis of some of the most exciting aspects of these cytoplasmic mechanisms of gene regulation is a major focus of this meeting. It is co-sponsored by the DFG (FOR855) and EMBL Corporate Partnership Program.
EMBL Heidelberg, 18 - 20 March 2010
Aims
The regulation of gene expression has been studied traditionally at the level of transcription. While a few examples of translational regulation were known, they were considered interesting exceptions to the general rule of regulation at the level of RNA synthesis. However, over the last few years it has become evident that several widespread posttranscriptional, mostly cytoplasmic mechanisms have profound effects on gene expression. All of these mechanisms ultimately contribute to control protein synthesis, either directly, by affecting the rate of translation, or indirectly, by affecting the abundance of mRNA. Some of them exert a qualitative, all-or-none control, for example by complete repression or elimination of certain mRNAs, others determine the intracellular location or the cell-type in which a particular RNA is translated, and still others have a quantitative effect, controlling the amount of protein made from a certain mRNA. The analysis of some of the most exciting aspects of these cytoplasmic mechanisms of gene regulation is a major focus of this meeting. It is co-sponsored by the DFG (FOR855) and EMBL Corporate Partnership Program.
Programme
Thursday 18 March 2010
- 16:45 Registration
- 18:45 - 19:00 Welcome Remarks
- 19:00 - 21:30 Synthesis and processing of mRNA
Friday 19 March 2010
- 09:00 - 10:30 The translation machinery and its regulation by proteins
- 10:30 - 11:00 Coffee Break
- 11:00 - 12:30 The translation machinery and its regulation by proteins (cont)
- 12:30 - 14:00 Lunch Break
- 14:00 - 15:30 miRNAs: biogenesis and function
- 15:30 - 16:00 Coffee Break
- 16:00 - 17:30 miRNAs: biogenesis and function (cont)
- 17:30 - 19:30 Poster Session with Aperitif
- 20:00 Dinner
Saturday 20 March 2010
- 09:00 - 10:30 Translational regulation of Viruses and Bacteria
- 10:30 - 11:00 Coffee Break
- 11:00 - 12:30 Translational regulation of Viruses and Bacteria (cont)
- 12:30 - 13:00 Lunch Break
- 14:00 - 15:30 RNA Turnover
- 15:30 - 16:00 Coffee Break
- 16:00 - 17:30 RNA Turnover (cont)
- 17:30 - 19:30 Poster Session with Aperitif
- 20:00 Gala Dinner
Invited Speakers
Patrick Cramer, University of Munich, Germany
Anne Ephrussi, EMBL Heidelberg, Germany
Witold Filipowicz, Friedrich Miescher Institute, Switzerland
Ulrike Gaul, University of Munich, Germany
Fatima Gebauer , CRG (Centre for Genomic Regulation), Spain
Matthias Gromeier , Duke University, USA
Alan Hinnebusch, National Institutes of Health, USA
Ralf Jansen, University of Tübingen, Germany
Jens Lykke-Andersen , University of California San Diego, USA
Raul Mendez, CRG (Centre for Genomic Regulation), Spain
Karla Neugebauer, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Dinshaw Patel, Sloan-Kettering Institute, USA
Sébastien Pfeffer, University of Strasbourg, France
Tom Pieler, University of Göttingen, Germany
Peter Sarnow, Stanford University, USA
Robert Singer, Yeshiva University, USA
Mikiko Siomi, Keio University, Japan
Nahum Sonenberg, McGiIl University, Canada
Bertrand Séraphin , CNRS, France
David Tollervey , University of Edinburgh, United Kingdom
Jörg Vogel, Max Planck Institute for Infection Biology, Germany
Registration
Click here to register.
Registration types and fees:
Academia: 375 EUR
Student: 325 EUR
The registration fee includes on-site catering, conference material and local transportation.
Participants are expected to meet their own accomodation and travel expenses.
Scientific Organisers
Matthias Hentze, EMBL, Heidelberg, Germany
Elmar Wahle , University of Halle, Germany
Additional Information
Fellowships available for this meeting:
15 Registration fee Fellowships to cover registration fees. These are for PhD Students.
3 PhD travel grants to cover up to 230 EUR of travel costs.
These are competitive awards and will be selected on the basis of scientific merit and motivation.
To apply for a Registration fellowship or a travel grant, please register for the conference. Once you receive the link to the abstract submission area, please indicate here for which fellowship you would like to apply and explain your motivation for attending this meeting (limited to 255 characters with spaces). Fellowships will be announced shortly after the registration process is closed.
Contact
For inquiries regarding the Sponsoring Options or the Sponsorship Order Form, please contact :
Antje Seeck - Marketing Officer
For other administrative issues please contact:
Gwen Sanderson - Course & Conference Office
Institutional Sponsors
