Staff at EMBL
Dr. Anne-Claude Gavin
Group Leader
Gavin Group
Joint appointment in the Genome Biology Unit
EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
E-mail:
Biography
PhD 1992, University of Geneva, Switzerland.
Postdoctoral research at EMBL.
Director, Molecular and Cell Biology, Cellzome AG, Heidelberg.
Group Leader at EMBL since 2005.
Publications
Impact of genome reduction on bacterial metabolism and its regulation. Yus E., Maier T., Michalodimitrakis K., van Noort V., Yamada T., Chen W.-H., Wodke J.A.H., Güell M., Martínez S., Bourgeois R., Kühner S., Raineri E., Letunic I., Kalinina O.V., Rode M., Herrmann R., Gutiérrez-Gallego R., Russell R.B., Gavin, A.C., Bork, P. and Serrano L. Science 2009 326 1263-1268
Proteome organization in a genome-reduced bacterium.
Kühner S., van Noort V., Betts M.J., Leo-Macias A., Batisse C., Rode M., Yamada T., Maier T., Bader S., Beltran-Alvarez P., Castaño-Diez D., Chen W.H., Devos D., Güell Cargol M., Norambuena T., Racke I., Rybin V., Schmidt A., Yus E., Aebersold R., Herrmann R., Böttcher B., Frangakis A.S., Russell R.B., Serrano L., Bork, P. and Gavin, A.C.
Science, 2009, 326, 1235-1240
Full text
Transcriptome complexity in a genome-reduced bacterium. Güell M., van Noort V., Yus E., Chen W.-H., Leigh-Bell J., Michalodimitrakis K., Yamada T., Arumugam M., Doerks T., Kühner S., Rode M., Suyama M., Gavin, A.C., Bork, P. and Serrano L. Science 2009 326 1268-1271
Meeting report on the 7th World Congress of the Human Proteome Organization (HUPO) in Amsterdam: Proteome Biology. Gavin, A.C., Aebersold, R. & Heck, A.J. Mol Cell Proteomics. 2008 Nov;7(11):2288-91. PubMed
Drug target identification using side-effect similarity. Campillos, M., Kuhn, M., Gavin, A.C., Jensen, L.J. & Bork, P. Science. 2008 Jul 11;321(5886):263-6. PubMed
Interaction networks for systems biology. Bader, S., Kuhner, S. & Gavin, A.C. FEBS Lett. 2008 Apr 9;582(8):1220-4. Epub 2008 Feb 20. PubMed
The social network of a cell: Recent advances in interactome mapping. Charbonnier, S., Gallego, O. & Gavin, A.C. Biotechnol Annu Rev. 2008;14:1-28. PubMed
The minimum information required for reporting a molecular interaction experiment (MIMIx). Orchard, S., Salwinski, L., Kerrien, S., Montecchi-Palazzi, L., Oesterheld, M., Stumpflen, V., Ceol, A., Chatr-Aryamontri, A., Armstrong, J., Woollard, P., Salama, J.J., Moore, S., Wojcik, J., Bader, G.D., Vidal, M., Cusick, M.E., Gerstein, M., Gavin, A.C., Superti-Furga, G., Greenblatt, J., Bader, J., Uetz, P., Tyers, M., Legrain, P., Fields, S., Mulder, N., Gilson, M., Niepmann, M., Burgoon, L., Rivas Jde, L., Prieto, C., Perreau, V.M., Hogue, C., Mewes, H.W., Apweiler, R., Xenarios, I., Eisenberg, D., Cesareni, G. & Hermjakob, H. Nat Biotechnol. 2007 Aug;25(8):894-8. PubMed
New perspectives on an old disease: proteomics in cancer research. Gallego, O. & Gavin, A.C. Genome Biol. 2007 Apr 30;8(4):303. PubMed
Towards quantitative analysis of proteome dynamics. Kuhner, S. & Gavin, A.C. Nat Biotechnol. 2007 Mar;25(3):298-300. PubMed
Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction. Cheusova, T., Khan, M.A., Schubert, S.W., Gavin, A.C., Buchou, T., Jacob, G., Sticht, H., Allende, J., Boldyreff, B., Brenner, H.R. & Hashemolhosseini, S. Genes Dev. 2006 Jul 1;20(13):1800-16. PubMed
Proteome survey reveals modularity of the yeast cell machinery. Gavin, A.C., Aloy, P., Grandi, P., Krause, R., Boesche, M., Marzioch, M., Rau, C., Jensen, L.J., Bastuck, S., Dumpelfeld, B., Edelmann, A., Heurtier, M.A., Hoffman, V., Hoefert, C., Klein, K., Hudak, M., Michon, A.M., Schelder, M., Schirle, M., Remor, M., Rudi, T., Hooper, S., Bauer, A., Bouwmeester, T., Casari, G., Drewes, G., Neubauer, G., Rick, J.M., Kuster, B., Bork, P., Russell, R.B. & Superti-Furga, G. Nature. 2006 Mar 30;440(7084):631-6. Epub 2006 Jan 22. PubMed
Protein co-membership and biochemical affinity purifications. Gavin, A.C. & Hopf, C. Drug Discovery Today: Technology 2006
Expanding the frontiers of proteomics. Gavin, A.C. & Heck, A. Drug Discovery Today: Technology 2006
Keystone symposia: proteomics and bioinformatics and systems and biology. Gavin, A.C. Expert Rev. Proteomics 2005;2:291-3.
Structure-based assembly of protein complexes in yeast. Aloy, P., Böttcher, B., Ceulemans, H., Leutwein, C., Mellwig, C., Fischer, S., Gavin, A.C., Bork, P., Superti-Furga, G., Serrano, L. & Russell, R.B. Science 2004 Mar 26;303(5666):2026-9. PubMed
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Bouwmeester, T., Bauch, A., Ruffner, H., Angrand, P.O., Bergamini, G., Croughton, K., Cruciat, C., Eberhard, D., Gagneur, J., Ghidelli, S., Hopf, C., Huhse, B., Mangano, R., Michon, A.M., Schirle, M., Schlegl, J., Schwab, M., Stein, M.A., Bauer, A., Casari, G., Drewes, G., Gavin, A.C., Jackson, D.B., Joberty, G., Neubauer, G., Rick, J., Kuster, B. & Superti-Furga, G. Nat Cell Biol 2004 Feb;6(2):97-105. Epub 2004 Jan 25. PubMed
Protein complexes and proteome organization from yeast to man. Gavin, A.C. & Superti-Furga, G. Curr Opin Chem Biol 2003 Feb;7(1):21-7. PubMed
90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Grandi, P., Rybin, V., Bassler, J., Petfalski, E., Strauss, D., Marzioch, M., Schafer, T., Kuster, B., Tschochner, H., Tollervey, D., Gavin, A.C. & Hurt, E. Mol Cell 2002 Jul;10(1):105-15. PubMed
A complex prediction: three-dimensional model of the yeast exosome. Aloy, P., Ciccarelli, F.D., Leutwein, C., Gavin, A.C., Superti-Furga, G., Bork, P., Böttcher, B. & Russell, R.B. EMBO Rep 2002 Jul;3(7):628-35. PubMed
Functional organization of the yeast proteome by systematic analysis of protein complexes. Gavin, A.C., Bosche, M., Krause, R., Grandi, P., Marzioch, M., Bauer, A., Schultz, J., Rick, J.M., Michon, A.M., Cruciat, C.M., Remor, M., Hofert, C., Schelder, M., Brajenovic, M., Ruffner, H., Merino, A., Klein, K., Hudak, M., Dickson, D., Rudi, T., Gnau, V., Bauch, A., Bastuck, S., Huhse, B., Leutwein, C., Heurtier, M.A., Copley, R.R., Edelmann, A., Querfurth, E., Rybin, V., Drewes, G., Raida, M., Bouwmeester, T., Bork, P., Seraphin, B., Kuster, B., Neubauer, G. & Superti-Furga, G. Nature 2002 Jan 10;415(6868):141-7. PubMed
Perspectives: signal transduction. Cell survival demands some Rsk. Nebreda, A.R. & Gavin, A.C. Science 1999 Nov 12;286(5443):1309-10 PubMed
A p90(rsk) mutant constitutively interacting with MAP kinase uncouples MAP kinase from p34(cdc2)/cyclin B activation in Xenopus oocytes. Gavin, A.C., Ni Ainle, A., Chierici, E., Jones, M. & Nebreda, A.R. Mol Biol Cell 1999 Sep;10(9):2971-86. PubMed
A MAP kinase docking site is required for phosphorylation and activation of p90(rsk)/MAPKAP kinase-1. Gavin, A.C. & Nebreda, A.R. Curr Biol 1999 Mar 11;9(5):281-4. PubMed
Cell survival demands some Rsk. Nebreda A.R. & Gavin A.C. Science 1999;286:309-1310.
Regulation and G2/M transition promoting activity of the human Abl tyrosine kinase in Xenopus oocytes. Dorey K., Barilà D., Gavin A.C., Nebreda A.R. & Superti-Furga G. Biol. Chem. 1999;380:223-230.
A link between MAP kinase and p34(cdc2)/cyclin B during oocyte maturation: p90(rsk) phosphorylates and inactivates the p34(cdc2) inhibitory kinase Myt1. Palmer, A., Gavin, A.C. & Nebreda, A.R. EMBO J 1998 Sep 1;17(17):5037-47. PubMed
Ribosomal S6 kinase p90rsk and mRNA cap-binding protein eIF4E phosphorylations correlate with MAP kinase activation during meiotic reinitiation of mouse oocytes. Gavin, A.C. & Schorderet-Slatkine, S. Mol Reprod Dev 1997 Mar;46(3):383-91. PubMed
An accumulation of p34cdc2 at the end of mouse oocyte growth correlates with the acquisition of meiotic competence. de Vant'ery, C., Gavin, A.C., Vassalli, J.D. & Schorderet-Slatkine, S. Dev Biol 1996 Mar 15;174(2):335-44. PubMed
Histone H1 kinase activity, germinal vesicle breakdown and M phase entry in mouse oocytes. Gavin, A.C., Cavadore, J.C. & Schorderet-Slatkine, S. J Cell Sci 1994 Jan;107 ( Pt 1):275-83. PubMed
Okadaic acid and p13suc1 modulate the reinitiation of meiosis in mouse oocytes. Gavin, A.C., Vassalli, J.D., Cavadore, J.C. & Schorderet-Slatkine, S. Mol Reprod Dev 1992 Nov;33(3):287-96. PubMed
Induction of M-phase entry of prophase-blocked mouse oocytes through microinjection of okadaic acid, a specific phosphatase inhibitor. Gavin, A.C., Tsukitani, Y. & Schorderet-Slatkine, S. Exp Cell Res 1991 Jan;192(1):75-81. PubMed
The interaction of lithium with forskolin-inhibited meiotic maturation of denuded mouse oocytes. Gavin, A.C. & Schorderet-Slatkine, S. Exp Cell Res 1988 Nov;179(1):298-302. PubMed